![]() ART is implemented in C++ with optimized algorithms and is highly efficient in read simulation. ART was used as a primary tool for the simulation study of the 1000 Genomes Project. ART can be used to test or benchmark a variety of method or tools for next-generation sequencing data analysis, including read alignment, de novo assembly, SNP and structure variation discovery. ART supports simulation of single-end, paired-end/mate-pair reads of three major commercial next-generation sequencing platforms: Illumina's Solexa, Roche's 454 and Applied Biosystems' SOLiD. ART can also simulate reads using user own read error model or quality profiles. ART simulates sequencing reads by mimicking real sequencing process with empirical error models or quality profiles summarized from large recalibrated sequencing data. Each package includes programs, documents and usage examples.ĪRT is a set of simulation tools to generate synthetic next-generation sequencing reads. ART is also available as Platform-independent C++ source packages. The binary packages of ART are available for three major operating systems: Linux, Macintosh, and Windows.
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